The first mRNA-based HIV vaccine is about to start human trials

Started by neurosis, August 18, 2021, 06:45 AM

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neurosis

Fairly exciting news.  

https://www.popsci.com/health/moderna-mrna-hiv-vaccine/">The same system Modern used for its COVID vaccine may also be able to help prevent HIV.

QuoteTwo of Moderna's mRNA-based HIV vaccines could start human trials this week, according to a new posting in the National Institutes of Health's clinical trial registry. The Phase I study would test the vaccines' safety, as well as collect basic data on whether they're inducing any kind of immunity, but would still need to go through Phases II and III to see how effective they might be.

These shots are based on the same technology as Moderna's COVID-19 vaccine: mRNA strands in the vaccine enter human cells, providing them with the code to make little bits of the same proteins that sit on the virus's exterior. Those proteins then act like test dummies for our immune systems to recognize, so immune cells in the future can identify and neutralize the actual virus. The process works incredibly well against SARS-CoV-2, and there's hope that it may work with HIV as well.

HIV has historically been extremely challenging to produce a vaccine for, in part because the virus integrates itself into the human genome rapidly—within 72 hours of transmission—thus producing an irreversible infection. This means "high levels of protective neutralizing antibodies must be present at the time of transmission to completely prevent infection," according to a July review paper in Nature Reviews Immunology. Many people infected with HIV don't develop those antibody levels, much less people exposed to the various attempted vaccines throughout the decades.

But the hope is that an mRNA vaccine could work where other candidates have failed.
I'll go back to being a conservative, when conservatives go back to being conservative.

Jim at Gentex

This one was already shot down by the US Patent Office when Fauci tried to obtain a patent for it, saying basically that his vaccine is not really a vaccine.

https://www.ieyenews.com/wp-content/uploads/2021/02/Screen-shot-2021-02-22-at-11.14.11-AM.png">

Read Dr. Martin's full report here:
https://www.ieyenews.com/the-fauci-covid-19-dossier-investigation-into-possible-illegal-patent-claims-resulting-in-millions-of-in-commercial-benefits/">https://www.ieyenews.com/the-fauci-covi ... -benefits/">https://www.ieyenews.com/the-fauci-covid-19-dossier-investigation-into-possible-illegal-patent-claims-resulting-in-millions-of-in-commercial-benefits/

BTW...that patent that was rejected was eventually approved...AFTER they changed the definition of what constitutes a 'vaccine'.

You can't make this stuff up.  :wallbash:
"Never argue with idiots.
They will drag you down to their level and beat you with experience." - Mark Twain

"Just because I don't care doesn't mean I don't understand." - Homer Simpson

Jeff

This is an interesting watch.


(on the topic of the flu shot) "If you are vaccinated in multiple years you are more likely to get severe disease you are more likely to have more viral replication and you are more likely to be hospitalized both in adults and in children.We are seeing the same thing in covid with the Delta variant."


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Zoober

Another jab I won't be getting.

RobertELee

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